Clinical Research Directory

Inclusion Criteria: * 60 to 88 years old patients; * Patient with cognitive complaint with MMSE ≥ 20performed within 6 months prior to enrollment (with or without dementia) * Patient with a socio-educational level ≥ 3 * Presence of hyperintensities of moderate to high grade on the last MRI or old scan (grades C and D on the modified Scheltens scale, grades 2/3 Fazekas). * Hypertension defined by a Systolic Blood Pressure (SBP) and / or a Diastolic Blood Pressure (DBP) ≥ 140/90 mmHg, treated or not * Affiliation to a social security system * Informed consent given, signed consent Exclusion Criteria: * Presence of severe orthostatic hypotension defined as a decrease of 30 mmHg in SBP standing within 3 minutes * Contraindication to MRI (presence of ferromagnetic foreign body (especially some intracranial clips, some heart valves, intraocular foreign bodies, metal prosthesis), subject carrying pacemaker, claustrophobic participants) * Severe diseases associated with a life expectancy of less than 3 months; * Major physical impairments that can interfere with the feasibility of the tests (sight, hearing ...) * Presence of another dementia different than Alzheimer's disease vascular dementia or mixed dementia, * Persons under guardianship; * Secondary hypertension: renovascular hypertension, primary aldosteronism, pheochromocytoma ...; * Patient already receiving 4 or more antihypertensive drugs at maximum dosage * Patient participating in another clinical research study on drug requiring exclusion period * severe renal impairment