Clinical Research Directory

Inclusion Criteria: All patients fulfilling the following criteria: * Age ≥ 18 years * Patient with suspected severe infection defined by the existence of a suspected infection AND * Hypotension before vascular fluid loading AND/OR * Lactataemia greater than 4 mmol/l AND/OR * Glasgow scale lower than 13 AND/OR * Mottling score greater than 2 * Patient with a septic shock Exclusion Criteria: * Age \<18 years or Unable * Pregnant * Severe concomitant pathology requiring urgent care(i.e.epilepsy) * Status "not to be reanimated" life expectancy less than 6 months with no indication of reanimation support ( prior decision on care limitation). * Fulminans purpura * True allergy to beta-lactam defined by an angioedema or by an anaphylactic shock during a prior exposure to beta-lactam. * Patient who have already received hemodynamic optimization or antibiotic treatment before the MICU's (Mobile Intensive Care Unit) care.