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Antimicrobial Photodynamic Therapy in the Endodontic Treatment of Anterior Primary Teeth With Pulp Necrosis
Sponsor: University of Nove de Julho
Summary
This randomized controlled clinical trial evaluated the immediate reduction in intracanal microbial load and the short-term clinical and radiographic progression of anterior primary teeth with pulp necrosis after conventional endodontic treatment or antimicrobial photodynamic therapy (aPDT). Seven children aged 2 to 5 years contributed 20 eligible single-rooted anterior primary teeth. Teeth were randomized to conventional endodontic treatment (10 teeth) or aPDT (10 teeth). The primary outcome was intracanal microbial load before and immediately after the assigned first-session intervention. Clinical outcomes were assessed at 7 days, 1 month, and 3 months, and radiographic outcomes were assessed at 1 and 3 months.
Official title: Antimicrobial Photodynamic Therapy in the Endodontic Treatment of Anterior Primary Teeth With Pulp Necrosis: A Randomized Controlled Clinical Trial With Microbiological Analysis and Blinded Assessment of Clinical and Radiographic Outcomes
Key Details
Gender
All
Age Range
2 Years - 5 Years
Study Type
INTERVENTIONAL
Enrollment
7
Start Date
2025-11-01
Completion Date
2026-05-01
Last Updated
2026-09-16
Healthy Volunteers
No
Conditions
Interventions
Conventional Endodontic Treatment
Following coronal access, an initial microbiological sample (S1) was collected. Chemomechanical preparation was performed using K-files, Endo PTC, and irrigation and aspiration with 1% sodium hypochlorite. A second microbiological sample (S2) was then collected. Calcium hydroxide intracanal medication was placed, and the tooth was temporarily sealed. After 7 days, the medication was removed, the canal was irrigated with 1% sodium hypochlorite, and definitive root canal filling was performed using Guedes-Pinto iodoform paste.
Antimicrobial Photodynamic Therapy
Following coronal access, an initial microbiological sample (S1) was collected. Methylene blue at 0.005% was placed inside the root canal for a 3-minute pre-irradiation period. Irradiation was performed using a Therapy XT red laser at 660 nm, 100 mW, for 90 seconds, delivering 9 J through an intracanal optical fiber. No chemomechanical preparation, instrumentation, or sodium hypochlorite irrigation was performed before S2. After irrigation with sterile saline, the second microbiological sample (S2) was collected. Calcium hydroxide intracanal medication was placed, and the tooth was temporarily sealed. After 7 days, the medication was removed, the canal was irrigated with 1% sodium hypochlorite, and definitive root canal filling was performed using Guedes-Pinto iodoform paste.
Locations (1)
University of Nove de Julho
São Paulo, Brazil