Clinical Research Directory

Inclusion Criteria: * Adult children of AD patient: First-degree descendant of an AD patient (following diagnosis as define in protocol). * Age: 45 to 64 years old. * Long-term commitment to the study: baseline and follow-up visits. Potential participants have to agree to undergo to all the procedures described in the protocol. Exclusion Criteria: * Cognitive impairment: to be included the participant must show no signs of objective cognitive impairment. * Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the protocol. * Illiteracy or functional illiteracy. * Any contraindication to any test or procedure at the time of study inclusion. * Family history of monogenic AD. * Not willing to undergo one or more of the tests and procedures described in the protocol at baseline.