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Trial of Routine Abdominal Wall Closure Versus Reinforcement With TIGR Matrix Onlay
Sponsor: Karolinska Institutet
Summary
Patients with at least two risk factors for incisional hernia undergoing abdominal surgery are eligible for inclusion. After accepting informed consent, patients are randomized into either closing the abdominal wall in a regular way with fascial sutures, or closing with fascial sutures together with placing a TIGR mesh as described. All patients are then monitored for signs of infection, wound rupture, incisional hernias, subcutaneous seroma as well as postoperative symptoms. All patients will be followed for at least 5 years. One year postoperatively, a computer scan is performed to detect asymptomatic incisional hernias.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2026-01-01
Completion Date
2027-06-30
Last Updated
2025-08-14
Healthy Volunteers
No
Interventions
TIGR Matrix
Reinforcement of the suture line with resorbable mesh
Control
Closure of the abdomen with conventional technique
Locations (1)
Karolinska University Hospital, Center for Digestive Diseases
Stockholm, Sweden