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COMPLETED
NCT02497235
PHASE1

A Phase 1 Positron Emission Tomography Study to Measure Cholesterol 24S-Hydroxylase Target Occupancy of TAK-935

Sponsor: Takeda

View on ClinicalTrials.gov

Summary

The purpose of this study is to determine the brain cholesterol 24S-hydroxylase (CH24H) enzyme occupancy of TAK-935 after single oral dose in healthy participants using the positron emission tomography (PET) ligand \[18F\]MNI-792 and PET imaging and to determine the relationship of occupancy to TAK-935 exposure.

Official title: An Open-Label, Positron Emission Tomography, Phase 1 Study With [18F]MNI-792 to Determine Cholesterol 24S-Hydroxylase Target Occupancy of TAK-935 After Single-Dose Oral Administration in Healthy Subjects.

Key Details

Gender

All

Age Range

19 Years - 55 Years

Study Type

INTERVENTIONAL

Enrollment

11

Start Date

2015-07

Completion Date

2016-01

Last Updated

2026-09-15

Healthy Volunteers

Yes

Interventions

DRUG

TAK-935

TAK-935 oral solution.

DRUG

[18F]MNI-792 (tracer)

\[18F\]MNI-792 injection.

Locations (1)

New Haven, Connecticut, United States