Clinical Research Directory

Inclusion Criteria: * Adults (aged 18-45 years) with type 1 diabetes * Participants must be able to be fasting prior to study visit and give informed consent. Exclusion Criteria: * Non-type 1 diabetes * History of eGFR \<60 ml/min/1.73m2 or microalbuminuria or greater * History of hypocalcemia or at risk of hypocalcemia * Taking allopurinol or uric acid altering medications * Ketogenic diet * Ketonuria * Taking phosphorus binders (e.g. sevelamer) * Pregnant or breastfeeding * Taking the following medications which may interact with sodium bicarbonate (e.g. phentermine, pseudoephedrine, antifungal medication, cephalosporin antibiotics \[e.g. Keflex\], tetracycline antibiotics \[e.g. doxycycline\], steroids or lithium) * Taking SGLT-2 inhibitors * Taking blood pressure medications