Clinical Research Directory

Inclusion Criteria: 1. All patients with multi-vessel coronary artery disease undergoing elective or urgent first time coronary artery bypass grafting (CABG). 2. All patients undergoing diagnostic angiography and suspected to have multi-vessel disease for referral to CABG 3. Patients requiring both on-pump or off-pump CABG are accepted, as long as a arterial revascularisation is planned. 4. The patients must be over the age of 18. 5. CABG is the only procedure being conducted Exclusion Criteria: 1. Planned simultaneous surgical procedure unrelated to coronary revascularization (e.g. valve repair/replacement, aneurysmectomy, carotid endarterectomy or carotid stenting) 2. Redo CABG, or a percutaneous coronary intervention (PCI) within the last 6 months. 3. Severe renal insufficiency (preoperative creatinine \>150umol/L) contraindicating postoperative coronary angiography 4. Significant leukopenia, neutropenia, thrombocytopenia, anemia, or known bleeding diathesis 5. Women who are pregnant or are seeking to become pregnant 6. Must not have severe congestive heart failure (class III or IV New York Heart Association) at enrollment 7. Left ventricular ejection fraction less than 30% 8. Prior history of significant bleeding that might be expected to recur with CABG 9. Prisoners or institutionalized individuals 10. Geographic inaccessibility for the follow-up visits required by protocol 11. Concurrent enrollment in another clinical trial 12. Extra-cardiac illness that is expected to limit survival to less than 5 years