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Urinary Biomarkers of OI Pathobiology
Sponsor: Baylor College of Medicine
Summary
Osteogenesis imperfecta (OI) is a rare inherited disorder that causes bones to break easily. Individuals with osteogenesis imperfecta break bones often and may have other problems, including hearing loss, dental problems, pain and difficulty getting around. Before the genetic cause of OI was known, OI was classified into four types. Each type was based upon the symptoms and severity of OI. In most people with OI, the cause is a change in one of the genes that makes a protein called type 1 collagen. Some doctors now classify OI both on how severe it is as well as which gene is causing OI. When people classify OI this way, there are more than 10 types of OI. The current laboratory testing to determine OI subtype involves the collection of blood and/or skin cells.
Official title: Cross-Linked Collagen Peptides as a Urinary Biomarker of OI Pathobiology
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
25
Start Date
2015-08-17
Completion Date
2026-08-31
Last Updated
2025-12-01
Healthy Volunteers
Yes
Conditions
Locations (7)
University of California Los Angeles
Los Angeles, California, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
Hospital for Special Surgery
New York, New York, United States
Oregon Health Science University
Portland, Oregon, United States
Baylor College of Medicine
Houston, Texas, United States
Shriners Hospital for Children
Milwauke, Wisconsin, United States
Shriners Hospital for Children
Montreal, Quebec, Canada