Clinical Research Directory

Inclusion Criteria: * 3 years or more after injury * Motor complete SCI (AIS A and B) or AIS C or D who are non-ambulatory * SCI C07-T12 * 155-191 centimeters tall * Weigh less than 113 kilograms * Have a Modified Ashworth Scale (MAS) score of less than 3 in both lower extremities * Have sufficient upper body strength to complete sit to sit transfers * Women of childbearing potential must agree to use contraceptive measures during participation in the study. They also will be required to have a negative pregnancy test (urine or serum) before receiving an imaging studies. Exclusion Criteria: * Current enrollment in another clinical trial * Pregnancy * Orthostatic hypotension with symptomatic fall in blood pressure \>30 mmHg when upright * An active grade 2 or greater pressure ulcer that can be worsened by walking in the device * Lower extremity contractures that interfere with the ability to wear the device * An unhealed limb or pelvic bone fracture history of other neurological disease (e.g. stroke, peripheral neuropathy, myopathy) * Active treatment for epilepsy or thyroid disorders * Current use of medications potentially affecting bone health (bisphosphonates, androgenic steroids, estrogenic steroids, lithium, glucocorticoid use for more than 3 months) * Women with osteoporosis detected at baseline DXA testing due to the high rate of study-related fractures observed in this group * Subjects with MRI-incompatible implants, pumps, or neurostimulators may be enrolled but will not undergo MRI studies