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Role of the Foregut in Nutrient Metabolism in Lean and Obese Humans
Sponsor: Vanderbilt University Medical Center
Summary
The overall hypothesis of this proposal is that nutrient sensing in the foregut regulates metabolic hormone secretion and nutrient metabolism via enteric neural signals, and these mechanisms might be defective in obesity.
Key Details
Gender
All
Age Range
20 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
27
Start Date
2015-09
Completion Date
2022-12-08
Last Updated
2026-06-11
Healthy Volunteers
Yes
Conditions
Interventions
benzocaine
0.5% benzocaine solution in saline/hydrochloric acid administered by intraduodenal infusion one time (6 ml bolus followed by 75 ml/hour for 105 minutes)
placebo
Placebo (saline) solution administered by intraduodenal infusion one time (6 ml bolus followed by 75 ml/hour for 105 minutes)
Locations (1)
Vanderbilt University Medical Center
Nashville, Tennessee, United States