Clinical Research Directory

Inclusion Criteria: * Male or female subject older than 40 years of age at the enrollment * Fulfill below conditions A and B A. The evidence of cirrhosis of any etiology within 12 months prior to screening Definition of cirrhosis by any of following methods 1. Histologically by liver biopsy; 2. Non-histologically by evidence of portal hypertension in the presence of chronic liver disease; * Evidence of portal hypertension, including any of followings; * The identification of splenomegaly on ultrasonography, CT, or MRI examinations with typical features of cirrhosis * The identification of esophageal or gastric varices on endoscopic examination B. Risk Index larger than 2.33; Risk Index = 1.65 (if the prothrombin activity is \<=75%) + 1.41 (if the age is 50 years or older) + 0.92 (if the platelet count is \<=100,000/mm3) + 0.74 (if the presence of HCV is positive). Exclusion Criteria: * Presence of liver cancer or other intrahepatic malignancy * Has a history of malignancy within previous 5 years * Is pregnant or breast-feeding