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Role of Epoxyeicosatrienoic Acids in Chronic Allograft Nephropathy - The TRANSPLANT-EETs Study
Sponsor: University Hospital, Rouen
Summary
Endothelial lesions within the transplanted kidney are a major determinant of chronic allograft nephropathy. Epoxyeicosatrienoic acids (EETs) are endothelium-derived hyperpolarizing factors with anti-inflammatory, antiproliferative and vasodilator properties. The main goal of the investigators' study is to evaluate whether genetic polymorphisms of specific enzymes responsible for the bioavailability of EETs are associated with post-transplant kidney function. To this end, 80 kidney transplant recipients will be included. Prespecified genetic polymorphisms of CYP 2J2, CYP 2C8, CYP 2C9, CYP 2C9, CYP 2C19 and EPHX2 will be determined. Kidney function will be recorded 3, 6, 12 and 36 months after transplantation. Flow-mediated dilatation, EETs and circulating biomarkers of endothelial function will be measured in the radial artery. The expected results of this study to provide preliminary evidence supporting a beneficial role of an increase in the bioavailability of EETs in kidney transplant recipients.
Official title: Role of Epoxyeicosatrienoic Acids in Chronic Allograft Nephropathy
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2014-03
Completion Date
2016-12
Last Updated
2026-04-27
Healthy Volunteers
No
Conditions
Interventions
Blood sampling
Blood sampling is done for Kidney transplant recipients for evaluation of the polymorphisms and EETs dosage
flow-mediated distal stimulation of the forearm radial artery by cutaneous heating
Flow-mediated distal stimulation of the forearm radial artery by cutaneous heating for Kidney transplant recipients
Locations (1)
Rouen University Hospital
Rouen, France