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Efficacy and Tolerance Comparison Between Subconjunctival Injection of Triamcinolone and Intravitreal Implant of Dexamethasone for the Treatment of Inflammatory Macular Edema
Sponsor: Nantes University Hospital
Summary
Corticosteroids, whether injected peri- or intra-ocularly, remain indispensable tools of the therapeutic arsenal in treating inflammatory macular edema. However, a few years ago, only triamcinolone acetonide was available to ophthalmologists. This molecule, developed initially for rheumatological or dermatological use, has been increasingly deployed in ophthalmology, while still off-label. In 2011, the delivery system of dexamethasone from biodegradable and injectable implant into the vitreous cavity obtained the label for inflammatory macular edema. This protocol is therefore designed to compare the efficacy and safety of peri- and intra-ocular injections of corticosteroids in the treatment of inflammatory macular edema.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
114
Start Date
2016-01
Completion Date
2021-02-15
Last Updated
2026-09-14
Healthy Volunteers
No
Conditions
Interventions
Dexamethasone
Intravitreal implant at D0
Triamcinolone
Subconjunctival injection at 4 mm from the limbus at 6 o'clock
Locations (16)
CHU Angers
Angers, France
CHU de Bordeaux
Bordeaux, France
CHU de Brest
Brest, France
CHU de Dijon
Dijon, France
CHU de Grenoble
La Tronche, France
Hôpital Bicêtre (AP-HP)
Le Kremlin-Bicêtre, France
CHRU de Lille
Lille, France
Hopices Civils de Lyon
Lyon, France
CHU de Montpellier
Montpellier, France
CHU de Nantes
Nantes, France
CHU de Nice
Nice, France
Hôpital La Pitié-Salpêtrière (AP-HP)
Paris, France
Fondation Ophtalmologique Adolphe de Rothschild
Paris, France
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Paris, France
CHU de Tours
Tours, France
CHU de Nancy
Vandœuvre-lès-Nancy, France