Clinical Research Directory

Inclusion Criteria: * Subjects who the investigator believes can and will comply with the requirements of the protocol (i.e. return for follow-up visits, and able to converse with study personnel) * Age 18 years or older * Undergoing major cardiac surgery using cardiopulmonary bypass Exclusion Criteria: * Have not received influenza vaccination in the past or cannot be vaccinated due to previous severe reaction to influenza vaccine, egg, latex, or thimerosol allergies, or refusal of vaccination * Participant has received a community available influenza vaccine within \<6 months * History of Guillain-Barré syndrome * Immunosuppressive disorders or medications (including oral prednisone \>10 mg daily, recent chemotherapy treatment) * Emergency cases as determined by the investigator or physician