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Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
Sponsor: Hoffmann-La Roche
Summary
This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1/2/3, ROS1, or ALK gene fusion. Patients will be assigned to different baskets according to tumor type and gene fusion.
Official title: An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients With Locally Advanced or Metastatic Solid Tumors That Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
534
Start Date
2015-11-19
Completion Date
2026-05-14
Last Updated
2026-03-06
Healthy Volunteers
No
Conditions
Interventions
Entrectinib
TrkA/B/C, ROS1, and ALK inhibitor
Locations (130)
Dignity Health St Joseph's Hospital and Medical Center
Phoenix, Arizona, United States
Mayo Clinic
Phoenix, Arizona, United States
City of Hope Cancer Center
Duarte, California, United States
City of Hope Duarte - Comprehensive Cancer Center, Investigational Drug Services
Duarte, California, United States
Scripps Clinic
La Jolla, California, United States
University of California San Diego Moores Cancer Center
La Jolla, California, United States
Southern California Kaiser Permanente
Los Angeles, California, United States
University of Southern California Medical Center
Los Angeles, California, United States
Univ Of California Irvine College Of Medicine
Orange, California, United States
UCSF Mount Zion Medical Ctr
San Francisco, California, United States
UCSF Mission Bay
San Francisco, California, United States
Sarcoma Oncology Center
Santa Monica, California, United States
Sarcoma Oncology Research Center LLC
Santa Monica, California, United States
University of Colorado Cancer Center
Aurora, Colorado, United States
Yale University
New Haven, Connecticut, United States
Georgetown University Medical Center Lombardi Cancer Center
Washington D.C., District of Columbia, United States
Florida Cancer Specialists - Sarasota
Sarasota, Florida, United States
H. Lee Moffitt Cancer Center and Research Inst.
Tampa, Florida, United States
Moffitt Cancer Center
Tampa, Florida, United States
University Cancer & Blood Center, LLC
Athens, Georgia, United States
Winship Cancer Institute
Atlanta, Georgia, United States
Southeastern Regional Medical Center, Inc.
Newnan, Georgia, United States
Northwestern University
Chicago, Illinois, United States
Advocate Medical Group - Park Ridge, Luther Lane - Oncology
Park Ridge, Illinois, United States
Midwestern Regional Medical Center
Zion, Illinois, United States
Weinberg Cancer Institution at Franklin Square
Baltimore, Maryland, United States
Massachusetts General Hosp CAR
Boston, Massachusetts, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Dana Farber Cancer Institute
Boston, Massachusetts, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States
Karmanos Cancer Center
Detroit, Michigan, United States
Henry Ford Hospital
Detroit, Michigan, United States
Regents of the University of Minnesota
Minneapolis, Minnesota, United States
Washington University
St Louis, Missouri, United States
Comprehensive Cancer Centers of Nevada (CCCN) - Central Valley
Las Vegas, Nevada, United States
North Shore Hem Onc Associates
East Setauket, New York, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Atrium Health Levine Cancer Institute
Charlotte, North Carolina, United States
Levine Cancer Institute
Charlotte, North Carolina, United States
Duke Cancer Institute
Durham, North Carolina, United States
Ohio State University
Columbus, Ohio, United States
OSU, James Cancer Hospital
Columbus, Ohio, United States
Cancer Treatment Centers of America
Tulsa, Oklahoma, United States
Oregon Health & Science University
Portland, Oregon, United States
Oregon Health & Science Univ
Portland, Oregon, United States
Mary Crowley Medical Research Center
Dallas, Texas, United States
University of Texas MD Anderson Cancer Center
Houston, Texas, United States
Baylor Scott & White Health
Temple, Texas, United States
University of Utah Hospitals & Clinics
Salt Lake City, Utah, United States
Virginia Cancer Specialists, PC
Fairfax, Virginia, United States
Virginia Oncology Associates - Hampton
Norfolk, Virginia, United States
University of Washington Seattle Cancer Care Alliance
Seattle, Washington, United States
Liverpool Hospital
Liverpool, New South Wales, Australia
Newcastle Private Hospital
Newcastle, New South Wales, Australia
Flinders Medical Centre
Bedford Park, South Australia, Australia
Austin Health
Heidelberg, Victoria, Australia
Pharmacy
Edegem, Belgium
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, China
Sichuan Cancer Hospital
Chengdu, Sichuan, China
Beijing Cancer Hospital
Beijing, China
Cancer Center of Guangzhou Medical University
Guangzhou, China
Zhejiang Cancer Hospital
Hangzhou, China
Harbin Medical University Cancer Hospital
Harbin, China
Shanghai chest hospital
Shanghai, China
Fudan University Shanghai Cancer Center
Shanghai, China
Shenzhen People's Hospital
Shenzhen, China
Institut de Cancerologie de l Ouest
Angers, France
Institut Bergonie
Bordeaux, France
Centre Leon Berard
Lyon, France
Hôpital de la Timone
Marseille, France
Hôpital Nord - AP-HM Marseille#
Marseille, France
Institut de Recherche en Cancérologie de Montpellier
Montpellier, France
Institut Curie
Paris, France
Institut De Cancerologie De L'ouest - Rene Gauducheau - Biology
Saint-Herblain, France
Institut Claudius Regaud
Toulouse, France
Institut Gustave Roussy
Villejuif, France
Evang. Lungenklinik Berlin Klinik für Pneumologie
Berlin, Germany
Universitaetsklinikum Koeln
Cologne, Germany
Universitaetsklinikum Carl Gustav Carus an der TU Dresden
Dresden, Germany
Universitaetsmedizin Goettingen
Göttingen, Germany
NCT Uniklinikum Heidelberg
Heidelberg, Germany
Princess Margaret Hospital
Hong Kong, Hong Kong
The University of Hong Kong
Hong Kong, Hong Kong
Queen Elizabeth Hospital
Kowloon, Hong Kong
The Chinese University of Hong Kong
Shatin, Hong Kong
Seconda Università degli Studi di Napoli
Naples, Campania, Italy
Università Campus Bio-Medico di Roma
Rome, Lazio, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Lombardy, Italy
Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda)
Milan, Lombardy, Italy
Azienda Ospedaliero Universitaria Pisana
Pisa, Tuscany, Italy
Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia
Perugia, Umbria, Italy
IOV - Istituto Oncologico Veneto - IRCCS
Padova, Veneto, Italy
Aichi Cancer Center Hospital
Aichi, Japan
National Cancer Center Hospital
Chūō, Japan
NHO Kyushu Cancer Center
Fukuoka, Japan
Hyogo Cancer Center, Dept of Respiratory Medicine
Hyōgo, Japan
National Cancer Center Hospital
Kashiwa-shi, Japan
NHO Shikoku Cancer Center
Matsuyama, Japan
Miyagi Cancer Center
Miyagi, Japan
Niigata Cancer Center Hospital
Niigata, Japan
Osaka City General Hospital
Osaka, Japan
Kindai University Hospital
Osaka, Japan
Shizuoka Cancer Center
Shizuoka, Japan
NKI The Netherlands Cancer Institute
Amsterdam, Netherlands
Leids Universitair Medisch Centrum
Leiden, Netherlands
Uniwersyteckie Centrum Kliniczne
Gda?sk, Poland
Centrum Onkologii-Instytut im.M.Sklodowskiej Curie
Gliwice, Poland
Szpital Kliniczny Przemienienia Panskiego Uni. Medycznego im. Karola Marcinkowskiego
Późna, Poland
Centrum Onkologii Instytut im. M. Sklodowskiej-Curie, Klinika Nowotworow Ukladu Chlonnego
Warsaw, Poland
National University Hospital
Singapore, Singapore
National Cancer Centre Singapore
Singapore, Singapore
Seoul National University Hospital
Seoul, South Korea
Asan Medical Center.
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Severance Hospital, Yonsei University Health System
Seoul, South Korea
Centro Nacional de Investigaciones Oncológicas(CNIO)
Fuenlabrada, Madrid, Spain
Vall d?Hebron Institute of Oncology (VHIO), Barcelona
Barcelona, Spain
Hospital Universitario Ramon y Cajal
Madrid, Spain
Hospital Universitario Clínico San Carlos
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario La Paz
Madrid, Spain
Hospital Clinico Universitario Virgen de la Victoria
Málaga, Spain
Hospital Universitario Virgen del Rocio
Seville, Spain
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Addenbrookes Hospital
Cambridge, United Kingdom
Sarah Cannon Research Institute
London, United Kingdom
The Christie
Manchester, United Kingdom