Clinical Research Directory
Browse clinical research sites, groups, and studies.
Patient-derived Xenograft Models of Tumor From Patients With Head and Neck Cancer
Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Summary
The investigators want to have a collection of fresh primary or recurrent tumor tissue for establishment of patients-derived xenografts in order to: generate a biobank of in vivo patient xenografts representing the different subgroups of tumors for head and neck cancer * perform genetic and transcriptional profiling of the primary, metastatic tumors and xenograft tumors * evaluate the efficacy of new targeted agents, whether or not in combination with standard treatment options * evaluate biomarkers of drug sensitivity * study primary and secondary (acquired) resistance in these models
Official title: Establishment of Primary Patient-derived Xenograft Models of Tumor From Patients With Head and Neck Cancer for Preclinical Evaluation of Targeted Therapies.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2015-09
Completion Date
2025-12
Last Updated
2024-12-03
Healthy Volunteers
No
Interventions
Local biopsy in the tumor
A tumor biopsy of 0.5 cm2 or more will be collected from every patient during surgery or endoscopy after informed consent and if there is enough material after review by the pathologist.
Locations (1)
Cliniques universitaires Saint-Luc
Brussels, Belgium