Clinical Research Directory

Inclusion Criteria: * Healthy subjects - Steps 1 and 2 * Age between 18 and 65 years old (2 age groups for step 2 : 18-30 et 40-65 years-old) * Written inform consent form signed * Affiliated to medical insurance * Alcohol consumption d'alcool \< 20g/j for women, \<30g/j for men * Patients with liver steatosis - Step 2 * More than 18 years -old * Written inform consent form signed * Affiliated to medical insurance * Patients with clean steatosis confirmed by histological results of a liver biopsy done the previous month * Alcohol consumption d'alcool \< 20g/j for women, \<30g/j for men Exclusion Criteria: * Healthy subjects - Step 1 * Exposure to chemical poisons (solvents, paints, drugs) in the previous 4 weeks * Pregnant women, lactating women, and women in age for procreation and without reliable contraception * Presence of ascites * Person under guardianship * Healthy subjects - Step 2 * Exposure to chemical poisons (solvents, paints, drugs) in the previous 4 weeks * Pregnant women, lactating women, and women in age for procreation and without reliable contraception * Contraindication to MRI * Presence of ascites * Person under guardianship * Healthy subjects - Steps 1 and 2 * Presence of liver tumor or ascites (diagnosed with MRI or ultrasonography) * Abnormal liver function tests (increase of transaminases, gammaGT) * Patients with liver steatosis - Step 2 * Exposure to chemical poisons (solvents, paints, drugs) in the previous 4 weeks * Pregnant women, lactating women, and women in age for procreation and without reliable contraception * Contraindication to MRI * Presence of ascites * liver tumor * Serology anti VHC+ or Ag HBs+ * Infection by HIV * Auto-immun hepatitis * Genetic hemochromatosis, Wilson disease, lake of alpha-1-antitrypsin * Fibrosis or liver cirrhosis at biopsy * Person under guardianship