Clinical Research Directory

Inclusion Criteria: * Existence of one or more metastases of of colorectal cancer (CRC) expressing the CEA , potentially accessible by surgical or thermo resection at the moment of the diagnosis or at relapse. OR * Isolated and progressive elevation of plasma CEA during the monitoring of CRC with high metastatic risk * More than 18 years * Negative pregnancy test for women of childbearing age. Women of childbearing age should take effective continuous contraception for 3 months. * At least 4 weeks after the last treatment and after recovery of potential toxicity * Karnofsky more than 70 or ECOG 0-1 * Life expectancy of at least 6 months * CEA positive immunohistochemistry or plasma CEA supperior or equal to the normal level * Creatinin less or equal 200 micromol/L * Signed informed consent * geographical proximity Exclusion Criteria: * Pregnancy or breastfeeding * Serious illness or comorbidity assessed risk * History of other cancer within 5 years, with the exception of skin carcinomas other than melanomas or in-situ carcinoma of the cervix * Anti-antibody presence in patients who have already received antibody * Hypersensitivity to antibodies or proteins * Intellectual inability to sign the informed consent * Insulin-dependent diabetic patient or non-insulin dependent