Clinical Research Directory

Inclusion Criteria: * Patient of age \> 18 years * Patient with previously peripheral implanted stent(s) located in or extending to the popliteal artery * Patient who received this stent between 3-36 months before inclusion * Patient with one or more in-stent restenosis lesion(s) \> 70% in the same arterial segment in association with clinical symptoms of claudication or an critical limb ischemia with Rutherford classification of 2, 3, 4 or 5 * Reference vessel diameter between 4 and 7 mm * Patient affiliated to a social security regimen * EC-approved consent form signed by the participant and the investigator (must be signed prior initiation of any study related intervention) Exclusion Criteria: * Life expectancy \>18 months * Patient already included in this study (recruitment of the contralateral leg is not allowed) * Patient contraindicated for the use of antiplatelet therapy * Pregnant or breast-feeding women * Patient with a target limb infection being treated * Patient with a procoagulant blood disease * Patient with history of contrast agents allergies * Patient with intolerance to paclitaxel * Patient with severe renal impairment (GFR \<30 ml / min / 1.73 m²) or patient with a creatinine clearance \<15 ml / min * External compression of previously implanted stent * Patient participating in any clinical trial using another investigational drug or product which could interfere with the interpretation of the trial results. * Patient under trusteeship or guardianship Angiographic exclusion criteria : * Inflow (above) severe lesion \>70% or occlusion untreated satisfactorily (residual lesion\> 50%) before the management of the target lesion * Perforation, dissection or lesions on the arterial network access requiring an assumption prior to randomization * Stent fracture grade 4 or 5 at the target lesion