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Peripheral Blood Stem Cell Transplantation for Hematologic Malignancies With Alpha Beta TCell and B Cell Depletion Using the CliniMACS Device
Sponsor: Julie-An M. Talano
Summary
This is a single arm pilot study for patients with hematologic malignancies with alternative donor sources receiving unrelated or partially matched related/Haploidentical mobilized peripheral stem cells (PSCs) using the CliniMACS system for Alpha Beta T cell depletion plus CD19+ B cell depletion to determine efficacy as determined by engraftment and GVHD, and one year leukemia free survival.
Official title: BT13BTθ51 Unrelated and Partially Matched Related Donor Peripheral Stem Cell Transplantation With Alpha Beta T Cell and B Cell Depletion For Patients With Hematologic Malignancies
Key Details
Gender
FEMALE
Age Range
Any - 23 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2015-10
Completion Date
2026-12
Last Updated
2026-05-01
Healthy Volunteers
No
Conditions
Interventions
CliniMACs
Depletion of Alpha Beta T cells in the PBSC graft
Locations (1)
Children's Hospital of Wisconsin
Milwaukee, Wisconsin, United States