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Aging, Geriatric Syndromes and Clonal Hematopoiesis
Sponsor: Washington University School of Medicine
Summary
In this study the investigators will incorporate a wide range of clinical variables associated with aging and cardiovascular disease to determine whether they are associated with mutation status independent of chronologic age. Clinically, aging can be operationalized using geriatric assessment, which entails a comprehensive multi-dimensional assessment of the health of an older adult, including measures of comorbidity, polypharmacy, functional status, cognition, depression, falls, social activities and social support. Given that aging is heterogeneous, geriatric assessment allows greater specificity for aging than chronological age alone.
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
OBSERVATIONAL
Enrollment
2000
Start Date
2016-03-10
Completion Date
2030-04-30
Last Updated
2025-04-25
Healthy Volunteers
Yes
Interventions
Cognitive Assessment
-Baseline and no more frequently than every 6 months until death
Activities of Daily Living Questionnaire
* 10 items about daily functional status * Baseline and no more frequently than every 6 months until death
Instrumental Activities of Daily Living, subscale of the OARS
* 7 items about daily functional status * Baseline and no more frequently than every 6 months until death
Karnofsky Self-reported Performance Rating Scale
* 1 item about daily functional status * Baseline and no more frequently than every 6 months until death
Number of Falls
* 1 item about daily functional status * Baseline and no more frequently than every 6 months until death
Physical Health Section, subscale of the OARS
* 13 items about comorbidity * Baseline and no more frequently than every 6 months until death
MOS Social Activity Survey
* 4 items about social activity * Baseline and no more frequently than every 6 months until death
Unintentional Weight Loss
* 2 items about nutrition * Baseline and no more frequently than every 6 months until death
Peripheral Blood Draw
-Baseline and no more frequently than every 6 months until death
Buccal Swab
* Participants will rinse their mouths 2 times with water for 20-30 seconds and discard the expectorated sample. One side of the inner cheek (buccal mucosa) will then be scraped with a cotton swab 20 times (alternatively, the tongue will be brushed 20 times with a toothbrush) * Baseline and no more frequently than every 6 months until death
Heart Health and Smoking History from BRFSS questionnaire
* 7 items about heart health and smoking history * Baseline and no more frequently than every 6 months until death
Gait Speed
* Research coordinator will test gait speed * Baseline and no more frequently than every 6 months until death
Grip Strength
* Research coordinator will test grip strength * Baseline and no more frequently than every 6 months until death
Height and Weight measurements
-Baseline and no more frequently than every 6 months until death
Blood pressure measurement
-Baseline and no more frequently than every 6 months until death
Optional bone marrow biopsy
-1 optional bone marrow biopsy
Blood draw for trauma measurements
-For Arm E only
Locations (1)
Washington University School of Medicine
St Louis, Missouri, United States