Clinical Research Directory
Browse clinical research sites, groups, and studies.
Effect of Treatment on Activity and Muscle Function in Pediatric Patients With Scoliosis
Sponsor: Mayo Clinic
Summary
This study will explore the relationship between skeletal muscle and physical activity in scoliosis patients to provide insight into both the etiology of scoliosis and potential ways to mitigate the potential harms of treatment.
Official title: Effect of Treatment on Activity and Muscle Function in Pediatric Patients With Scoliosis (SAMUS SCOLI)
Key Details
Gender
All
Age Range
9 Years - 16 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2015-11
Completion Date
2026-08
Last Updated
2025-09-15
Healthy Volunteers
No
Conditions
Interventions
Spinal Fusion Surgery
Participants with severe scoliosis curves requiring spinal fusion surgery.
Bracing
Participants with scoliosis curves that require brace treatment for at least the next year. Braces include monitors to record hours of brace wear, as is current standard of care.
Tri-axial Accelerometers
Four monitors are place on the participant (waist, thigh, both ankles), attached with straps. Periods of static and dynamic activity are measured based on accelerations in three orthogonal directions for 4 day's time while participating in regular daily activities.
Shear Wave Elastography (SWUE)
SWUE is an ultrasound technique for noninvasively evaluating the mechanical properties (stiffness) of skeletal muscle tissue. A commercial ultrasound scanner (Aixplorer from Supersonic Imagine, France) with 2D real time SWUE will be used. The Aixplorer uses ultrasonic push beams to produce shear waves in tissue. The shear wave propagation speed is inherently related to tissue mechanical properties and is used to create a quantitative 2D elastogram of the tissue.
Locations (1)
Mayo Clinic in Rochester
Rochester, Minnesota, United States