Clinical Research Directory

Inclusion Criteria: * Hormone replacement therapy (HRT) for oestrogen deficiency symptoms in perimenopausal and postmenopausal women. * Prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of, or contraindicated for, other medicinal products approved for the prevention of osteoporosis. Exclusion Criteria: * Known, past or suspected breast cancer; * Known or suspected oestrogen-dependent malignant tumours (eg endometrial cancer); * Undiagnosed genital bleeding; * Untreated endometrial hyperplasia; * Previous or current venous thromboembolism (deep venous thrombosis,pulmonary embolism) * Known thrombophilic disorders (eg protein C, protein S, or antithrombin deficiency, see section. * Active or recent arterial thromboembolic disease (eg angina, myocardial infarction); * Acute liver disease, or a history of liver disease as long as liver function tests have failed to return to normal; * Known hypersensitivity to the active substances or to any of the excipients;