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RECRUITING
NCT02630121
PHASE4

Effect of Oxymetazoline Hydrochloride in Combination With Fluticasone Propionate on the Apnea Hypopnea Index (AHI) in Subject With Persistent Nasal Congestion and Mild Obstructive Sleep Apnea

Sponsor: University of South Florida

View on ClinicalTrials.gov

Summary

The addition of intranasal oxymetazoline for two weeks to already instituted optimal doses of intranasal fluticasone propionate will decrease the total number of obstructive apneas and hypopneas per hour of sleep in subjects with perennial allergic or non-allergic rhinitis and mild obstructive sleep apnea who have persistent nasal congestion despite maximum doses of NGCS.

Official title: Effect of Oxymetazoline Hydrochloride in Combination With Fluticasone Propionate on the Apnea Hypopnea Index (AHI) in Subject With Persistent Nasal Congestion and Mild Obstructive Sleep Apnea. A Double Blinded Placebo Controlled, Crossover Prospective Trial.

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

52

Start Date

2023-04-01

Completion Date

2026-04

Last Updated

2025-01-24

Healthy Volunteers

No

Interventions

DRUG

Oxymetazoline Hydrochloride

Proportion of the subjects with 50% reduction in AHI.

DRUG

Placebo

Proportion of the subjects with 50% reduction in AHI.

Locations (1)

Usf Asthma Allergy and Immunology Cru

Tampa, Florida, United States