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CLAD Phenotype Specific Risk Factors and Mechanisms
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Summary
While many patients experience benefits from transplant, complications such as infections and lung rejection may affect long term survival and quality of life. In this study doctors are looking at a complication called Chronic Lung Allograft Dysfunction (CLAD). CLAD is thought to be chronic rejection of the lung by the immune system and is the leading cause of death after lung transplantation. The purpose of this study is to help doctors determine: * why some people get CLAD and others do not * how patients who get CLAD do after CLAD is diagnosed * how CLAD may affect quality of life
Official title: A Prospective Multicenter Observational Cohort Study to Define the Risks Factors, Mechanisms, and Manifestations of Chronic Lung Allograft Dysfunction (CLAD) Phenotypes (CTOT-20)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
884
Start Date
2015-12-22
Completion Date
2019-11-30
Last Updated
2026-09-25
Healthy Volunteers
No
Conditions
Interventions
Blood Draw
Bronchoscopy
Locations (5)
University of California, Los Angeles
Los Angeles, California, United States
Johns Hopkins University
Baltimore, Maryland, United States
Duke University
Durham, North Carolina, United States
Cleveland Clinic
Cleveland, Ohio, United States
University of Toronto
Toronto, Ontario, Canada