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NCT02631720

CLAD Phenotype Specific Risk Factors and Mechanisms

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

View on ClinicalTrials.gov

Summary

While many patients experience benefits from transplant, complications such as infections and lung rejection may affect long term survival and quality of life. In this study doctors are looking at a complication called Chronic Lung Allograft Dysfunction (CLAD). CLAD is thought to be chronic rejection of the lung by the immune system and is the leading cause of death after lung transplantation. The purpose of this study is to help doctors determine: * why some people get CLAD and others do not * how patients who get CLAD do after CLAD is diagnosed * how CLAD may affect quality of life

Official title: A Prospective Multicenter Observational Cohort Study to Define the Risks Factors, Mechanisms, and Manifestations of Chronic Lung Allograft Dysfunction (CLAD) Phenotypes (CTOT-20)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

884

Start Date

2015-12-22

Completion Date

2019-11-30

Last Updated

2026-09-25

Healthy Volunteers

No

Interventions

PROCEDURE

Blood Draw

PROCEDURE

Bronchoscopy

Locations (5)

University of California, Los Angeles

Los Angeles, California, United States

Johns Hopkins University

Baltimore, Maryland, United States

Duke University

Durham, North Carolina, United States

Cleveland Clinic

Cleveland, Ohio, United States

University of Toronto

Toronto, Ontario, Canada