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Study of the Involvement of IL-17 / IL-22 Pathway in Bacterial Exacerbations of COPD
Sponsor: University Hospital, Lille
Summary
Chronic obstructive pulmonary disease (COPD) is a worldwide chronic inflammatory disease of the airways linked to environmental exposure. The chronic course of COPD is often interrupted by acute exacerbations which have a major impact on the morbidity and mortality of COPD patients. A bacterial etiology for these exacerbations is common (almost 50%). Moreover, airway bacterial colonization linked to an increased susceptibility is observed in COPD patients. Effective Th17 immune response is needed to develop a good response against bacteria. Thus, this study aims to demonstrate that there is a defective IL-17/ IL-22 response to bacteria in COPD leading to airway bacterial colonization and infection.
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2018-07-04
Completion Date
2028-07
Last Updated
2023-01-27
Healthy Volunteers
No
Interventions
Sample collecting
Collect sputum, blood and nasopharyngeal swab during the exacerbation and at steady state 8 to 16 weeks later.
Lung function measure
Measure lung function and follow it during 4 years
Locations (4)
University hospital of Lille
Lille, France
Roubaix hospital
Roubaix, France
Seclin hospital
Seclin, France
Tourcoing hospital
Tourcoing, France