Clinical Research Directory
Browse clinical research sites, groups, and studies.
Optimal Treatment for Recurrent Clostridium Difficile
Sponsor: VA Office of Research and Development
Summary
The purpose of this study is to determine whether fidaxomicin and vancomycin followed by taper and pulse vancomycin treatment are superior to standard vancomycin treatment for the treatment of recurrent Clostridium difficile infection.
Official title: CSP #596 - Optimal Treatment for Recurrent Clostridium Difficile Infection
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
308
Start Date
2016-02-19
Completion Date
2024-08-31
Last Updated
2026-08-21
Healthy Volunteers
No
Interventions
Fidaxomicin
200 mg PO twice daily for 10 days
Vancomycin with Taper/Pulse
125 mg PO four times daily for 10 days, followed by 125 mg once daily x 7 days, then once every other day x 7 days, then once every 3rd day x 7 days
Vancomycin
125 mg PO for times daily for 10 days
Locations (33)
Phoenix VA Health Care System, Phoenix, AZ
Phoenix, Arizona, United States
Southern Arizona VA Health Care System, Tucson, AZ
Tucson, Arizona, United States
Central Arkansas Veterans Healthcare System, Little Rock, AR
Little Rock, Arkansas, United States
VA Loma Linda Healthcare System, Loma Linda, CA
Loma Linda, California, United States
VA Long Beach Healthcare System, Long Beach, CA
Long Beach, California, United States
VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, California, United States
VA Northern California Health Care System, Mather, CA
Sacramento, California, United States
VA San Diego Healthcare System, San Diego, CA
San Diego, California, United States
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
West Los Angeles, California, United States
Rocky Mountain Regional VA Medical Center, Aurora, CO
Aurora, Colorado, United States
Bay Pines VA Healthcare System, Pay Pines, FL
Bay Pines, Florida, United States
North Florida/South Georgia Veterans Health System, Gainesville, FL
Gainesville, Florida, United States
James A. Haley Veterans' Hospital, Tampa, FL
Tampa, Florida, United States
Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, United States
Jesse Brown VA Medical Center, Chicago, IL
Chicago, Illinois, United States
Edward Hines Jr. VA Hospital, Hines, IL
Hines, Illinois, United States
Edward Hines Jr. VA Hospital, Hines, IL
Hines, Illinois, United States
Rehabilitation R&D Service, Baltimore, MD
Baltimore, Maryland, United States
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, Massachusetts, United States
VA Ann Arbor Healthcare System, Ann Arbor, MI
Ann Arbor, Michigan, United States
John D. Dingell VA Medical Center, Detroit, MI
Detroit, Michigan, United States
Asheville VA Medical Center, Asheville, NC
Asheville, North Carolina, United States
Durham VA Medical Center, Durham, NC
Durham, North Carolina, United States
Louis Stokes VA Medical Center, Cleveland, OH
Cleveland, Ohio, United States
Oklahoma City VA Medical Center, Oklahoma City, OK
Oklahoma City, Oklahoma, United States
VA Portland Health Care System, Portland, OR
Portland, Oregon, United States
VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX
Dallas, Texas, United States
Michael E. DeBakey VA Medical Center, Houston, TX
Houston, Texas, United States
South Texas Health Care System, San Antonio, TX
San Antonio, Texas, United States
VA Salt Lake City Health Care System, Salt Lake City, UT
Salt Lake City, Utah, United States
VA Puget Sound Health Care System Seattle Division, Seattle, WA
Seattle, Washington, United States
Clement J. Zablocki VA Medical Center, Milwaukee, WI
Milwaukee, Wisconsin, United States
VA Caribbean Healthcare System, San Juan, PR
San Juan, Puerto Rico