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Hemodynamic Instability Prevented With Polaramine® Infusion Before Extracorporeal Circulation
Sponsor: University Hospital, Bordeaux
Summary
This single-institution randomized controlled trial prospective will enrolled 48 patients scheduled for an aortic valve replacement. The objective of the present investigation is to determine the role of Polaramine® on reducing hemodynamic instability after separation from cardiopulmonary bypass (CPB) during cardiac surgery. Our hypothesis is that Polaramine® play an important role reducing dysfunction of the autonomic nervous system and hemodynamic stability after separation from CPB.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
18
Start Date
2016-06-05
Completion Date
2017-07-18
Last Updated
2026-06-22
Healthy Volunteers
No
Interventions
dexchlorpheniramine (Polaramine®) injection
5 minutes before CPB, patients will receive 10 mg (2 ml) of Polaramine®
Placebo injection
5 minutes before CPB, patients will receive 2 ml of normal saline
Locations (1)
CHU de Bordeaux
Pessac, France