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Mechanisms for Vascular Dysfunction and Exercise Tolerance in CF
Sponsor: Augusta University
Summary
Cystic fibrosis has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections. However, the physiological mechanisms for this reduced exercise capacity are unknown. The investigators recently published the first evidence of systemic vascular dysfunction in patients with CF. Therefore, it is reasonable to suspect that the blood vessels are involved with exercise intolerance in CF. This study will look at how and if oxidative stress contributes to both artery dysfunction and exercise intolerance in CF.
Key Details
Gender
All
Age Range
7 Years - Any
Study Type
INTERVENTIONAL
Enrollment
13
Start Date
2015-04
Completion Date
2027-01
Last Updated
2025-01-28
Healthy Volunteers
Yes
Conditions
Interventions
Acute Antioxidant
Flow-Mediated Dilation will be determined at baseline and 2 hours following acute antioxidant treatment
Chronic Antioxidant
Flow-Mediated Dilation will be determined at baseline, week 4, week 8, and week 12.
Placebo
Flow-Mediated Dilation will be determined at baseline and 2 hours following acute antioxidant treatment
Locations (1)
Georgia Prevention Institute
Augusta, Georgia, United States