Clinical Research Directory

Inclusion Criteria: A included patient must be coincident with all the following items: * Age 0\~18 years old * Any organ system symptoms consistent with PCD and being conform to the clinical diagnostic standard of Katergener syndrome or being coincident with at least two following specific tests: * Abnormal ciliary beat frequency or movement by the high speed photography microscope * Abnormal ciliary structure through the electronic microscopy * The nasal NO decreased significantly * The target gene mutation found * The clinical diagnostic criteria of the Katergener syndrome: ① bronchial expansion; ② sinusitis or nasal polyps; ③ transposition of viscera and (or) dextrocardia. * If all the typical clinical manifestations but only 1 specific test with positive results, can also be included in the registration of suspected PCD cases * Consent to provide the related clinical specimen to the certain hospital * The guardians of the patients fully understand the purpose of the study, volunteer their children to participate in this study, and sign informed consent. Exclusion Criteria: Subject will be excluded if she or he has one of the following: * It is unable to provide complete medical records or the current condition can not accept the diagnosis process * She or he cannot agree to participate in the study.