Clinical Research Directory

Inclusion Criteria: * Aged 15 and older * Subjects/parents/legal guardian is able to read and comprehend study procedure and consent forms. * Have already been prescribed Doxycycline by their physician for acne or to be eligible to be prescribed Doxycycline for acne * Have acne that is diagnosed by a board certified dermatologist. Exclusion Criteria: * Those who have received systemic antibiotics within four weeks of starting the study. * Those who have received systemic isotretinoin within six weeks of starting the study. * Those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome * Those who are pregnant, prisoners or cognitively impaired. * Those subjects who are currently using proton pump inhibits (as studies have shown this may impact the gut microbiome) (4) * Those who have a BMI greater than \>30 kg/m2, as studies have shown a reduction in the variability of intestinal microbes within this population (5). * Those who have initiated or changed brand of oral contraceptive pill within 4 weeks of starting the study. * Those who have autoimmune disorders as this group has been shown to have an altered microbiome (6) * Those who have diabetes (6), immunodeficiencies (7), inflammatory bowel disease (6), hypercholesterolemia, as these groups have been shown to have altered gut microbiomes * Those who have taken oral probiotic supplements (8) within 4 weeks of starting the study * Given the nature of the instructions that need to be adhered to for accurate collection of samples and this data, non-English speaking individuals will be excluded from this pilot study. * Allergies to the tetracycline group of antibiotics * Those who do not fit the inclusion criteria