Clinical Research Directory

Inclusion Criteria: 1. Male and female children less than 6 years of age. 2. A diagnosis of adrenal insufficiency as confirmed by an inappropriately low cortisol usually with other supporting tests. 3. Receiving appropriate adrenocortical replacement therapy (hydrocortisone with/without fludrocortisone). 4. Adequately hydrated and nourished. 5. Ability of parents/carers to understand and give written Informed Consent Exclusion Criteria: 1. Clinically evident acute adrenal insufficiency (adrenal crisis). 2. Inability of the child to take oral therapy. 3. Concomitant therapy (other than that required to treat adrenal insufficiency, Vitamin D, Fluoride, Thyroxine and growth hormone). 4. Subjects with clinical signs of acute infection or fever on Day 1. 5. Any surgical or medical condition which in the opinion of the investigator may place the subject at higher risk from his/her participation in the study. 6. Parents/carers of subjects unwilling to consent to saving and propagation of pseudonymised medical data for study reasons. 7. Subjects who are dependent on the investigator or the sponsor.