Clinical Research Directory
Browse clinical research sites, groups, and studies.
Role of the Striatal Cholinergic System in the Pathophysiology of Dystonia
Sponsor: University Hospital, Bordeaux
Summary
Dystonia is defined as a syndrome of sustained muscle contractions resulting in repetitive movements and abnormal postures. DYT1 is the most common form of genetic dystonia, but the link between genomic mutations and phenotypic expression remains largely unknown. Furthermore, secondary forms of dystonia have highlighted the role of the basal ganglia, particularly the putamen in the pathophysiology of the disease. Experimental results in a genetic model of dystonia in rodents suggest that cholinergic inter-neurons (ACh-I) of the putamen play a critical role in the pathological process of plasticity in the cortico-striatal synapse. However, these results have not been demonstrated in humans.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2016-01
Completion Date
2018-03-01
Last Updated
2026-05-14
Healthy Volunteers
Yes
Conditions
Interventions
PET (Positron Emission Tomography) imaging
Molecular imaging using a PET radiotracer of the vesicular acetylcholine transporter.
MRI : Magnetic Resonance Imaging
Multimodal MRI, MRI diffusion tensor (to study the microscopic structure of white matter) and functional MRI of the resting state (to study the functional organization of cerebral cholinergic networks at rest).
Locations (1)
CHU de Bordeaux
Bordeaux, France