Clinical Research Directory

Inclusion Criteria: 1. Patient is 14 years or older. 2. Diagnosed NF1, determined by American Academy of Neurology Guidelines (see Diagnosis section). 3. Tumor Location: cutaneous, trunk, or limbs only. 4. Tumor Type: superficial dermal neurofibromas ≤4mm deep. 5. Patient has provided written informed consent. 6. Patient is willing to and can comply with study follow-up requirements. 7. Absence of any other malignancy. Exclusion Criteria: 1. Life expectancy less than 3 years. 2. Pregnancy. 3. Cutaneous photosensitivity to the wavelengths used to active PDT. 4. A diagnosis of porphyria. 5. Allergy to aminolevulinic acid or any of the topical solution vehicle components. 6. Previous chemotherapy within 6 weeks of proposed PDT. 7. Other concurrent tumor therapy.