Clinical Research Directory

Inclusion Criteria: Subjects successfully completing study Infacort 003, whose inclusion criteria were: 1. Male and female children less than 6 years of age. 2. A diagnosis of adrenal insufficiency (AI) as confirmed by an inappropriately low cortisol usually with other supporting tests. 3. Receiving appropriate adrenocortical replacement therapy (hydrocortisone with/without fludrocortisone). 4. Adequately hydrated and nourished. In addition, the parents/carers must be able to understand and give written Informed Consent for this extension study. Exclusion Criteria: 1. Clinically evident acute AI (adrenal crisis) (Note: the subject can be re-evaluated for eligibility once the episode is over) 2. Inability of the child to take oral therapy 3. Subjects with clinical signs of acute infection or fever on inclusion (Note: the subject can be re-evaluated for eligibility once the episode is over) 4. Any surgical or medical condition that in the opinion of the Investigator may place the subject at higher risk from his/her participation in the study 5. Parents/carers of subjects unwilling to consent to saving and propagation of pseudonymised medical data for study reasons 6. Subjects who are in a dependent relationship with the Investigator or the Sponsor