Clinical Research Directory

Inclusion Criteria: 1. Subject´s written informed consent 2. Histologically and radiologically confirmed progressive neuroendocrine carcinoma of gastrointestinal, pancreatic or bronchial origin with multiple liver metastases. Progression in Clinical symptoms and tumor growth verified over the last 6 months on CT or MRI 3. Cancer that is not considered resectable for potential cure or tumor reduction 4. Patent portal vein and adequate liver perfusion 5. Liver dominant disease with involvement of \<60% of liver parenchyma 6. Karnofsky performance status of \>=70% 7. Life expectancy of \>=6 months 8. \>=18 years of age 9. Must use a reliable method of contraception if sexually active and of reproductive potential 10. Plasma creatinine \<105 ug/ml 11. Aspartate transaminase (AST), Alanine transaminase (ALT) and Alkaline Phosphatase (ALP) \<3.0-fold upper limit of normal 12. Total bilirubin \<2.0-fold upper limit of normal 13. Prothrombin time (PT)/International Normalized Ratio (INR) \<2.0 and Prothromboplastin time (PTT) within normal limits 14. Neutrophils \>1500/ml, hemoglobin \>100 g/L, platelets \>100 000/ml 15. Patients with functioning NET should have cover by somatostatin analog Exclusion Criteria: 1. Known chronic liver dysfunction Before the development of metastatic cancer (e.g. cirrhosis, chronic hepatitis) 2. Active infection, including documented HIV and hepatitis C 3. Any viral syndrome diagnosed within the previous 2 weeks 4. Chemotherapy within the previous 4 weeks Before the first treatment 5. Radiotherapy to the target tumor site within the last 24 weeks from the baseline CT scan 6. Concomitant malignancy 7. Pregnant or lactating females 8. Prior participation in any research protocol that involved administration of adenovirus vectors 9. Treatment with any other investigational therapy within the last 4 weeks, organ transplantation prior to treatment, severe cardiovascular, metabolic or pulmonary disease 10. Continuing treatment with any other cancer therapy