Clinical Research Directory

Inclusion Criteria: * Age 18 years or older. For participants included in WP2 (MRI), the maximum age is 70 years. * Diagnosis of Complex Regional Pain Syndrome (CRPS) according to the Budapest criteria. * CRPS affecting a single upper or lower limb. * Triggering trauma or onset of pain more than 3 months before inclusion. Exclusion Criteria: * Drug abuse. * Malignant or progressive disease, systemic disease, or neurodegenerative disease. * Other severe pain conditions. * Severe anxiety or depression. * Disabling fatigue or myalgic encephalomyelitis (ME). * Use of opioid medication exceeding 100 mg oral morphine equivalents (OMEQ). Additional Exclusion Criteria for WP2 (MRI): * History of seizures. * Neurological or neurosurgical disorders. * Significant cardiac or systemic illness. * Implanted metallic or electronic devices incompatible with MRI. * Diagnosis of a developmental disorder. * Current use of antipsychotic medications, benzodiazepines, or other pharmacological agents that may influence MRI measurements. * Pregnancy or lactation. * Phobia of MRI examination.