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Trial to Compare Radiation Fibrosis With Five Versus Three Fractions
Sponsor: Weill Medical College of Cornell University
Summary
Post meno-pausal women with T1 Breast cancers will be randomized to receive either 600 centiGray (cGy) X 5 over five consecutive days (arm 1) versus 800 cGy X 3 fractions given every other day (arm 2). Patients will complete treatment in one week. All patients will be followed a month after the completion of treatment then q6 months for the first year, then yearly for the next 10 years.
Official title: Prone Partial Breast Irradiation (PBI): Prospective Randomized Controlled Non-inferiority Trial to Compare Radiation Fibrosis With Five Versus Three Fractions
Key Details
Gender
FEMALE
Age Range
50 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
350
Start Date
2015-10-14
Completion Date
2027-12
Last Updated
2025-12-15
Healthy Volunteers
No
Conditions
Interventions
Arm 1 600 cGY x 5 fractions
Patients who are randomized to Arm 1 will receive either 600 cGY x 5 fractions over 5 consecutive days
Arm 2 800 cGY x 3 fractions
Patients who are randomized to Arm 2 will receive 800 cGY x 3 fractions given every other day
Locations (4)
University of Southern California
Los Angeles, California, United States
Weill Cornell Medical College
New York, New York, United States
Brooklyn Methodist Hospital - NewYork Presbyterian
New York, New York, United States
New York Presbyterian Hospital - Queens
New York, New York, United States