Clinical Research Directory

Inclusion Criteria: * hypertension confirmed with ambulatory blood pressure monitoring * primary aldosteronism demonstrated by hormonal assays: active renin (pg/ml) or plasma renin activity (ng/ml/h) and plasma aldosterone measured twice at baseline after an overnight fast, in sitting or recumbent position * selective adrenal venous sampling after 40 years of age * unilateral adrenal nod on CT scan \<4cm * adrenal radiofrequency ablation procedure of judged technically possible by radiologists Exclusion Criteria: * bilateral adrenal nods * primary aldosteronism due to bilateral adrenal hyperplasia or macronodular hyperplasia * lack of documented primary aldosteronism * maximum tumor diameter greater than 4 cm * Cushing syndrome or Pheochromocytoma * when adrenal venous sampling is refused by the patient * coagulopathy * pregnant women * patient with potentially inaccessible nodule