Clinical Research Directory

Inclusion Criteria: * Subject exposed at least one hour per day to passive smoking at work during at 1 year minimum for intervention arm and non exposed to passive smoking for control group. * Subject having signed informed consent * Subject with social security insurance or equivalent Exclusion Criteria: * Exposition to passive smoking at home * Active smokers (at least 1 cigarette per day or having drawn up active smoking for less than a month) * Medical history of homozygote familial hypercholesterolemia * Usage of lipid lowering treatment in the month before the inclusion * Hepatic active pathology or hepatocellular insufficiency * Severe kidney disease (with creatine clearance less than 30 ml per minute) * Evolutive cancer * Usage of concomitant treatment as : insulin, nitro-derivatives and statins * Medical history of alcoholism or drug use last year * Medical history of permanent systolic hypotension (systolic blood pressure less than 90 mmHg) or non controled hypertension (systolic blood pressure higher than 200 mmHg and diastolic blood pressure 110 mmHg) * Active cardiovascular disease * Psychological or medical conditions incompatible with the study according to investigator opinion * Participation to another study with experimental product or subject having received an study treatment within 4 weeks before inclusion * Impossibility to follow the study procedure * Pregnancy and breastfeeding * Subject protected by french law