Clinical Research Directory

-INCLUSION CRITERIA: 1. Adults age \>=18 years. 2. Signed informed consent for the trial. 3. At risk of occupational exposure to Ebola virus through laboratory, clinical contact, or field work, in the judgment of the investigator. 4. Females of childbearing potential must be willing to use effective methods of contraception, from at least 30 days prior to vaccination through 1 month following vaccination/booster, which would include: * oral contraceptives, either combined or progestogen alone * injectable progestogen * implants of etenogestrel or levonorgestrel * oestrogenic vaginal ring * percutaneous contraceptive patches * intrauterine device or intrauterine system * committed to abstinence from potentially reproductive sexual contact \[i.e. will NOT engage in heterosexual intercourse where both partners are capable of reproduction\] * surgical sterilization * male condom combined with a spermicide 5. All males must be willing to use effective methods of contraception for at least 1 month following vaccination/booster, which would include: * surgical sterilization * male condom combined with a spermicide 6. Willing to minimize blood and body fluid exposure to others for at least 14 days after vaccination/booster. This includes: * Use of effective barrier prophylaxis, such as latex condoms, during any sexual interaction (regardless of childbearing status or sexual orientation) * Avoiding the sharing of needles, razors, eating utensils, drinking from the same cup, or toothbrushes * Avoiding open-mouth kissing * Use of universal precautions in the health-care setting 7. Agrees not to receive another investigational agent between vaccination and the month 1 study visit (and booster and month 19 study visit). 8. Willing to forgo blood donation for one year from vaccination/booster. 9. Willing to accept randomization (boost versus no boost) at month 18 visit. EXCLUSION CRITERIA: 1. Any condition that would limit the ability of the participant to meet protocol requirements or would place the participant at unreasonable risk. Examples include: * Clinically significant medical condition, physical examination findings, clinically significant abnormal laboratory results, or past medical history with clinically significant implications for current health, per the investigator. A clinically significant condition or process includes but is not limited to: 1. A process that would adversely affect the systemic immune response 2. A process that would require medication that might adversely affect the systemic immune response 3. Any contraindication to repeated injections or blood draws 4. A condition that requires active medical intervention or monitoring to avert grave danger to the participant's health or well-being during the study period 5. A condition or process for which signs or symptoms could be confused with reactions to vaccine * Presence of any pre-existing illness or clinical history that, in the opinion of the investigator, would place the participant at an unreasonably increased risk through participation in this study. This includes but is not limited to: 1. Active malignancy 2. History of Guillain-Barre Syndrome 3. History of neurological disorder that may increase risk (history of encephalitis, stroke, or seizure) 4. Active autoimmune disorder requiring systemic immunosuppressive treatment * Any concomitant medication for which reported side effects or adverse events, in the judgment of the investigator, may interfere with assessment of safety. * Subjects who, in the judgment of the investigator, will be unlikely or unable to comply with the requirements of this protocol. 2. Pregnant or breast feeding (must have negative serum or urine pregnancy test on the day of vaccination, prior to vaccination) 3. Known allergy to the components of the rVSV∆G-ZEBOV-GP vaccine (V920) vaccine product (VSV, albumin, tris). 4. History of severe local or systemic reactions to any vaccination. 5. Received an investigational drug within 5 half-lives or 30 days, whichever is longer, prior to vaccination (Day 0)/booster (month 18). 6. Received killed vaccines 14 days before, or intention to receive within 7 days following, vaccination (Day 0)/booster (month 18). 7. Received live virus vaccines within 30 days before, or intention to receive live virus vaccines within 30 days following, vaccination (Day 0)/booster (month 18). 8. Received immunoglobulins and/or any blood products within the 120 days preceding vaccination (Day 0)/booster (month 18). 9. Received allergy treatment with antigen injections within 30 days before vaccination (Day 0)/booster (month 18). 10. Clinical evidence (e.g. oral temp \>38 degrees Celsius, systemic symptoms) of a systemic infection or other acute intercurrent illness at the proposed time of vaccination (Day 0)/booster (month 18).