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Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement
Sponsor: Dartmouth-Hitchcock Medical Center
Summary
PEPPER is a randomized study comparing the three most commonly used anticoagulants in North America in patients who have elected to undergo primary or revision hip or knee joint replacement surgery. The anticoagulants being compared are enteric coated aspirin, low intensity warfarin, and rivaroxaban.
Official title: Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement: Balancing Safety and Effectiveness
Key Details
Gender
All
Age Range
21 Years - Any
Study Type
INTERVENTIONAL
Enrollment
18883
Start Date
2016-12
Completion Date
2025-09
Last Updated
2026-10-05
Healthy Volunteers
No
Conditions
Interventions
Enteric Coated Aspirin
Warfarin
Rivaroxaban
Locations (32)
Mayo Clinic
Scottsdale, Arizona, United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
UCLA
Los Angeles, California, United States
Stanford University Hospital
Stanford, California, United States
Arthritis Surgery Research Foundation
South Miami, Florida, United States
Rush University Medical Center
Chicago, Illinois, United States
Indiana University
Indianapolis, Indiana, United States
Sinai Hospital
Baltimore, Maryland, United States
Johns Hopkins University
Baltimore, Maryland, United States
Brigham & Women's Hospital
Boston, Massachusetts, United States
Boston University Medical Center
Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Lahey Clinic
Burlington, Massachusetts, United States
Mayo Clinic
Rochester, Minnesota, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States
New York University
New York, New York, United States
Northwell Health
New York, New York, United States
Duke University Medical Center
Durham, North Carolina, United States
Cleveland Clinic
Cleveland, Ohio, United States
Penn State Hershey Med Center
Hershey, Pennsylvania, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Lifespan Health
East Providence, Rhode Island, United States
Medical University of South Carolina
Charleston, South Carolina, United States
University of Utah
Salt Lake City, Utah, United States
Anderson Orthopaedic Institute (VA)
Alexandria, Virginia, United States
University of Virginia
Charlottesville, Virginia, United States
Virginia Commonwealth University Medical Center
Richmond, Virginia, United States
University of Washington
Seattle, Washington, United States
West Virginia University
Morgantown, West Virginia, United States
London Health Sciences Centre
London, Ontario, Canada
University of Ottawa
Ottawa, Ontario, Canada