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ACTIVE NOT RECRUITING
NCT02810743
PHASE3

Substantially Improving the Cure Rate of High-risk BRCA1-like Breast Cancer

Sponsor: The Netherlands Cancer Institute

View on ClinicalTrials.gov

Summary

Investigator-initiated, international, multicentre, randomized, open-label, (neo)adjuvant phase III study in target population (stage III, HER2-negative, BRCA1-like breast cancer patients) comparing optimized standard-dose chemotherapy with intensified, alkylating chemotherapy with stem cell rescue.

Official title: Substantially Improving the Cure Rate of High-risk BRCA1-like Breast Cancer Patients With Personalized Therapy (SUBITO) - an International Randomized Phase III Trial

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

174

Start Date

2017-01-25

Completion Date

2033-12-01

Last Updated

2025-11-26

Healthy Volunteers

No

Conditions

Interventions

DRUG

ddAC-CP-Olaparib

ddAC-CP-Olaparib

DRUG

ddAC-mini CTC

ddAC - mini CTC

Locations (11)

Institut Paoli Calmettes

Marseille, France

Hopital Tenon, University Marie-Curie

Paris, France

Medical spectrum Twente

Enschede, Overijssel, Netherlands

Antoni van Leeuwenhoek

Amsterdam, Netherlands

AZVU

Amsterdam, Netherlands

University Medical Center Groningen

Groningen, Netherlands

LUMC

Leiden, Netherlands

Maastricht University Medical Center

Maastricht, Netherlands

Radboud UMC

Nijmegen, Netherlands

Erasmus Medical Center Cancer Institute

Rotterdam, Netherlands

University Medical Center Utrecht

Utrecht, Netherlands