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Substantially Improving the Cure Rate of High-risk BRCA1-like Breast Cancer
Sponsor: The Netherlands Cancer Institute
Summary
Investigator-initiated, international, multicentre, randomized, open-label, (neo)adjuvant phase III study in target population (stage III, HER2-negative, BRCA1-like breast cancer patients) comparing optimized standard-dose chemotherapy with intensified, alkylating chemotherapy with stem cell rescue.
Official title: Substantially Improving the Cure Rate of High-risk BRCA1-like Breast Cancer Patients With Personalized Therapy (SUBITO) - an International Randomized Phase III Trial
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
174
Start Date
2017-01-25
Completion Date
2033-12-01
Last Updated
2025-11-26
Healthy Volunteers
No
Conditions
Interventions
ddAC-CP-Olaparib
ddAC-CP-Olaparib
ddAC-mini CTC
ddAC - mini CTC
Locations (11)
Institut Paoli Calmettes
Marseille, France
Hopital Tenon, University Marie-Curie
Paris, France
Medical spectrum Twente
Enschede, Overijssel, Netherlands
Antoni van Leeuwenhoek
Amsterdam, Netherlands
AZVU
Amsterdam, Netherlands
University Medical Center Groningen
Groningen, Netherlands
LUMC
Leiden, Netherlands
Maastricht University Medical Center
Maastricht, Netherlands
Radboud UMC
Nijmegen, Netherlands
Erasmus Medical Center Cancer Institute
Rotterdam, Netherlands
University Medical Center Utrecht
Utrecht, Netherlands