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Dried Plums and Bone Health in Postmenopausal Women
Sponsor: Penn State University
Summary
Postmenopausal women often seek non-pharmacologic interventions for the protection of bone health. Previous research in humans and rodents has indicated that dietary dried plum consumption may be beneficial for bone health, especially in postmenopausal women. However, it is unknown in what quantity dried plums need to be consumed to be of benefit and through what mechanisms dried plums act to impact bone health. Therefore, the purpose of this study is to evaluate the impact of 52 weeks of dried plums consumption in varying quantities on bone mineral density (BMD), bone geometry, and estimated bone strength in postmenopausal women. The investigators also seek to evaluate the mechanisms underlying the effects of dried plums as a dietary supplement by assessing polyphenols and the bioavailable conjugated metabolites in the urine of postmenopausal women taking different doses of dietary dried plums. The investigators aim to further investigate the mechanisms of dried plum action on bone by measuring markers of bone metabolism in response to dried plum consumption.
Official title: Randomized Control Trial of Dietary Supplementation With Dried Plums on Bone Density, Geometry and Estimated Bone Strength in Postmenopausal Women
Key Details
Gender
FEMALE
Age Range
55 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
322
Start Date
2016-06-01
Completion Date
2026-12-31
Last Updated
2025-05-13
Healthy Volunteers
No
Conditions
Interventions
Dried Plum
Participants randomized to the 50g dried plum group will consume 6 dried plums per day for the duration of the 52 week intervention. Participants randomized to the 100g dried plum group will consume 12 dried plums per day for the duration of the 52 week intervention.
Calcium supplement
All participants will consume calcium supplements for the duration of baseline and intervention.
Vitamin D supplement
All participants will consume vitamin D supplements for the duration of baseline and intervention.
Locations (1)
Women's Health and Exercise Laboratories, The Pennsylvania State University
University Park, Pennsylvania, United States