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Metabolic Impact of Intermittent CPAP
Sponsor: Johns Hopkins University
Summary
Obstructive sleep apnea is a risk factor for diabetes and cardiovascular disease, by unknown mechanisms. The investigators hypothesize that sleep apnea changes glucose and lipid metabolism during sleep, which over time could lead to diabetes and cardiovascular disease. This study examines metabolic changes during sleep in patients with obstructive sleep apnea. Patients accustomed to continuous positive airway pressure (CPAP) therapy are enrolled to undergo sleep studies, either on CPAP therapy or after withdrawing from CPAP for 3 nights. During sleep, blood samples are obtained so that metabolic function can be compared between sleep apnea and CPAP nights.
Key Details
Gender
All
Age Range
20 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
144
Start Date
2016-07-10
Completion Date
2022-12-01
Last Updated
2026-09-24
Healthy Volunteers
No
Conditions
Interventions
CPAP withdrawal
CPAP is discontinued for 3 nights.
Locations (1)
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States