Clinical Research Directory

Inclusion Criteria: 1. Adult men and women 30+ years of age 2. Meet criteria for overweight or obesity via BMI or waist size 3. Underwent colonoscopy screening within the past 10 years 4. History of pathology-confirmed precancerous polyp of the colon or rectum; OR Colorectal cancer survivor who has completed treatment with adequate maintenance of bowel length (eligible: hemicolectomy or low anterior resection; ineligible: total or near total colectomy, greater than 10 cm of small bowel resection) and normalized bowel habits 5. English-speaking and reside in the greater Houston/outlying areas and/or willing to travel for study-related visits at MD Anderson 6. Ability to complete web-based dietary assessments twice per week 7. Willingness to provide stool samples and undergo venipuncture 8. Willingness to consume/avoid beans as instructed during the 16 weeks from randomization Exclusion Criteria: 1. Antibiotic use in the past month and unable/unwilling to be deferred to a later recruitment date 2. Current smoker 3. Heavy drinker (defined as more than 14 drinks per week) 4. Currently taking exclusionary prescription medications (including cytokines, immunosuppressive agents, chemopreventive drugs, bile acid sequestrants/selective cholesterol absorption inhibitors) 5. Regularly taking anti flatulence medications, probiotics and/or fiber supplements and unable/unwilling to discontinue for the purpose of the study 6. Major dietary restrictions relevant to the intervention 7. Hereditary colorectal cancer syndromes 8. Pregnant or lactating or planning to become pregnant