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Transplantation of Autologously Derived Mitochondria Following Ischemia
Sponsor: Boston Children's Hospital
Summary
The investigators propose a robust therapeutic intervention to ameliorate myocardial ischemia/ reperfusion injury and significantly decrease morbidity and mortality in patients requiring extracorporeal membrane oxygenation (ECMO), by direct injection of autogeneic mitochondria into the ischemic myocardium.
Official title: Transplantation of Autologously Derived Mitochondria for Protection Against Ischemia-reperfusion Injury Following Ischemia in Subjects on ECMO Support
Key Details
Gender
All
Age Range
Any - 17 Years
Study Type
INTERVENTIONAL
Enrollment
16
Start Date
2017-08-02
Completion Date
2027-06
Last Updated
2026-01-05
Healthy Volunteers
No
Interventions
autologous mitochondria transplantation
Autologous mitochondria obtained from the subject's own skeletal muscle will be injected or infused into the ischemic myocardium
Locations (1)
Boston Children's Hospital
Boston, Massachusetts, United States