Clinical Research Directory

Inclusion Criteria: * Adults aged ≤ 65 years, * Idiopathic PD (According to British Brain Bank Criteria) without any other known or suspected cause of Parkinsonism, * Hoehn and Yahr stage ≤ 2.5 in the best ON, * Disease duration ≥ 4 years, * Presence of fluctuations and/or dyskinesias for no more than 3 years, * One of the two following forms of impairment : * Impairment in activities of daily living (MDS-UPDRS II\>6) due to PD-symptoms despite medical treatment in the worst condition or, * Impairment of social and occupational functioning (measured with SOFAS) due to PD-symptoms despite medical treatment (51-80%), * PDQ39 completed, * Able to understand and remember the component of the study, * Written informed consent, * Patients covered with social insurance. Exclusion Criteria: * Dementia (MoCA \< 22), * Major uncontrolled depression at the time of assessment (BDI \> 25) or Bipolar disease, * Active hallucinations or history of hallucinations in the past year, * Need for nursing care, * Previous use of apomorphine pump treatment, * History of respiratory depression, * History of deep brain stimulation or lesional surgery for PD or intrajejunal L-Dopa, * Presence of severe freezing or clinically relevant postural instability leading to falls during the ON state, * Symptomatic clinically relevant and medically uncontrolled orthostatic hypotension, * Clinically relevant hepatic dysfunction (total bilirubin \>2.0 mg/dL, Alanine Amino Transferase (ALT) and Aspartate Amino Transferase (AST) \>2 times the upper limit of normal), * Clinically relevant renal dysfunction (serum creatinine \>2.0 mg/dL), * Pregnant and breastfeeding women, * Hypersensitivity to apomorphine or any excipients of the medicinal product, * Concomitant therapy or within 28 days prior to baseline with : alpha-methyl dopa, metoclopramide, reserpine, neuroleptics (except Clozapine), methylphenidate, or amphetamine, intrajejunal Ldopa, * History or current drug or alcohol abuse or dependencies, * Patients with a borderline QT interval corrected for heart rate according to Bazett's formula (QTc) of \>470 ms for male and \>480 ms for female at screening or history of long QT syndrome; * Adults legally protected (under judicial protection, guardianship or supervision), persons deprived of their liberty.