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Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION)
Sponsor: EMD Serono Research & Development Institute, Inc.
Summary
This study looked at how effective the study drug (tepotinib) was at stopping the growth and spread of lung cancer. This study also measures a number of other things including safety of the study drug and the side effects, how body processes the study drug, or how the study drug affects your quality of life. The study also has an optional pharmacogenetic research part. Pharmacogenetic research is an important way to try to understand the role of genetics in human disease and how genes impact the effectiveness of drugs, because differences in genes can change the way a person responds to a particular drug.
Official title: A Phase II Single-arm Trial to Investigate Tepotinib in Advanced (Locally Advanced or Metastatic) Non-small Cell Lung Cancer With METex14 Skipping Alterations or MET Amplification (VISION)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
337
Start Date
2016-09-13
Completion Date
2026-04-30
Last Updated
2025-12-23
Healthy Volunteers
No
Conditions
Interventions
Tepotinib
Subjects will receive 500 milligram (mg) of tepotinib once daily in cycles of 21-day duration until disease progression, death, adverse event (AE) leading to discontinuation or withdrawal of consent.
Locations (176)
City of Hope Cancer Center
Duarte, California, United States
California Cancer Associates for Research & Excellence, Inc.
Encinitas, California, United States
St. Joseph Hospital
Orange, California, United States
Torrance Health Association
Redondo Beach, California, United States
St Joseph Heritage Healthcare
Santa Rosa, California, United States
Rocky Mountain Cancer Centers, LLP
Denver, Colorado, United States
Holy Cross Hospital Inc.
Fort Lauderdale, Florida, United States
H. Lee Moffitt Cancer Center and Research Institute, Inc
Tampa, Florida, United States
University Cancer & Blood Center, LLC
Athens, Georgia, United States
Winship Cancer Institute
Atlanta, Georgia, United States
University of Chicago Medical Center
Chicago, Illinois, United States
Ingalls Hospital
Harvey, Illinois, United States
Community Regional Cancer Care
Indianapolis, Indiana, United States
Center for Cancer and Blood Disorders
Bethesda, Maryland, United States
For Recruiting Locations in the United States, please Contact U.S. Medical Information
Rockland, Massachusetts, United States
St. Louis Cancer Care, LLP
Bridgeton, Missouri, United States
Saint Louis University Cancer Center
St Louis, Missouri, United States
Saint Louis University
St Louis, Missouri, United States
Summit Medical Group, P.A.
Berkeley Heights, New Jersey, United States
Summit Medical Group
Berkeley Heights, New Jersey, United States
Regional Cancer Care Associates East Brunswick
East Brunswick, New Jersey, United States
Somerset Hematology Oncology Associates - Somerville Location
East Brunswick, New Jersey, United States
Hackensack University Medical Center PARTNER
Hackensack, New Jersey, United States
Prospect Medical Offices, LLC
Midland Park, New Jersey, United States
The Valley Hospital
Ridgewood, New Jersey, United States
Memorial Sloan Kettering Cancer Center - Commack
Commack, New York, United States
Memorial Sloan Kettering Cancer Center, West Harrison Regional Outpatient Pavilion
Harrison, New York, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
UC Health Clinical Trials Office
Cincinnati, Ohio, United States
University of Cincinnati - PARENT
Cincinnati, Ohio, United States
Tennessee Oncology
Nashville, Tennessee, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Texas Oncology, P.A. - Austin
Austin, Texas, United States
Texas Oncology, PA
Beaumont, Texas, United States
University of Texas MD Anderson Cancer Center
Houston, Texas, United States
Virginia Cancer Specialists, PC
Fairfax, Virginia, United States
Swedish Medical Center
Seattle, Washington, United States
Wenatchee Valley Hospital & Clinics - ATTN: Jay Johnson
Wenatchee, Washington, United States
Wenatchee Valley Medical Center Oncology
Wenatchee, Washington, United States
LKH - Universitätsklinikum der PMU Salzburg - Innere Med III/Hämatologie und Onkologie
Salzburg, Austria
UZ Antwerpen
Edegem, Belgium
UZ Antwerpen
Edegem, Belgium
CHU Ambroise Paré
Mons, Belgium
CHU Ambroise Paré
Mons, Belgium
AZ Delta
Roeselare, Belgium
AZ Delta
Roeselare, Belgium
Beijing Hospital
Beijing, China
Peking University Cancer Hospital
Beijing, China
Jilin Cancer Hospital - Oncology
Changchun, China
Hunan Cancer Hospital
Changsha, China
Sichuan Cancer Hospital
Chengdu, China
West China Hospital, Sichuan University
Chengdu, China
Guangdong General Hospital
Guangzhou, China
Zhejiang Cancer Hospita
Hangzhou, China
Affiliated Tumor Hospital of Harbin Medical University
Harbin, China
Anhui Provincial Cancer Hospital aka West Branch of Anhui Province Hospital
Hefei, China
Jinan Central Hospital
Jinan, China
Linyi Tumor Hospital
Linyi, China
Jiangsu Province Hospital
Nanjing, China
Shanghai Cancer Hospital, Fudan University
Shanghai, China
Liaoning Cancer Hospital & Institute
Shenyang, China
The Affiliated Cancer Hospital of Xinjiang Medical university
Ürümqi, China
Groupe Hospitalier Sud - Hôpital Haut-Lévêque
Pessac, Gironde, France
CHU de Toulouse - Hôpital Larrey
Toulouse, Haute Garonne, France
ICO - Site René Gauducheau
Saint-Herblain, Loire Atlantique, France
Clinique Mutualiste de l'Estuaire
Saint-Nazaire, Loire Atlantique, France
ICO - Site Paul Papin
Angers, Maine Et Loire, France
Centre Hospitalier de Cholet
Cholet, Maine Et Loire, France
Centre Hospitalier de Bretagne Sud
Lorient, Morbihan, France
Hopital Albert Calmette - CHU Lille
Lille, Nord, France
Centre Hospitalier de la côte Basque
Bayonne, Pyrenees Atlantiques, France
Centre Hospitalier Départemental Les Oudairies
La Roche-sur-Yon, Vendee, France
ICO - Site Paul Papin
Angers, France
Centre Hospitalier de la côte Basque
Bayonne, France
Centre Hospitalier de Cholet
Cholet, France
Centre Hospitalier Intercommunal de Créteil
Créteil, France
Centre Hospitalier Départemental Les Oudairies
La Roche-sur-Yon, France
Hopital Albert Calmette - CHU Lille
Lille, France
Centre Hospitalier de Bretagne Sud
Lorient, France
Hôpital Saint-Louis
Paris, France
Groupe Hospitalier Sud - Hôpital Haut-Lévêque
Pessac, France
ICO - Site René Gauducheau
Saint-Herblain, France
Clinique Mutualiste de l'Estuaire
Saint-Nazaire, France
CHU de Toulouse - Hôpital Larrey
Toulouse, France
POIS Leipzig GbR
Leipzig, Saxony, Germany
Charite Universitaetsmedizin Berlin - Campus Charite Mitte
Berlin, Germany
Klinikum Chemnitz gGmbH
Chemnitz, Germany
Staedtisches Klinikum Dresden Standort Dresden-Friedrichstadt
Dresden, Germany
Universitaetsklinikum Carl Gustav Carus TU Dresden
Dresden, Germany
Helios Klinikum Erfurt
Erfurt, Germany
Asklepios Fachkliniken Muenchen-Gauting
Gauting, Germany
SRH Wald-Klinikum Gera gGmbH
Gera, Germany
Universitaetsmedizin Goettingen
Göttingen, Germany
Evangelisches Krankenhaus Hamm GmbH
Hamm, Germany
Universitaetsklinikum Heidelberg
Heidelberg, Germany
Universitaetsklinikum des Saarlandes
Homburg / Saar, Germany
POIS Leipzig GbR
Leipzig, Germany
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
Mainz, Germany
Pius-Hospital Oldenburg
Oldenburg, Germany
Soroka University Medical Center
Beersheba, Israel
Hadassah University Hospital - Ein Kerem
Jerusalem, Israel
Meir Medical Center
Kfar Saba, Israel
Rabin Medical Center-Beilinson Campus
Petah Tikva, Israel
Tel Aviv Sourasky Medical Center
Tel Aviv, Israel
Istituto Nazionale per la Ricerca sul Cancro di Genova
Genova, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
IEO Istituto Europeo di Oncologia
Milan, Italy
Seconda Università degli Studi di Napoli
Naples, Italy
Azienda Ospedaliera di Padova
Padova, Italy
IOV - Istituto Oncologico Veneto IRCCS
Padova, Italy
Ospedale Santa Maria di Cà Foncello
Padova, Italy
Azienda Ospedaliera San Camillo Forlanini
Roma, Italy
Università Campus Bio-Medico di Roma
Roma, Italy
Istituto Clinico Humanitas
Rozzano, Italy
NHO Kyushu Medical Center
Fukuoka, Japan
National Cancer Center Hospital East
Kashiwa-shi, Japan
Saitama Cancer Center
Kitaadachi-gun, Japan
Kurume University Hospital
Kurume-shi, Japan
NHO Shikoku Cancer Center
Matsuyama, Japan
Nagoya University Hospital
Nagoya, Japan
Niigata Cancer Center Hospital
Niigata, Japan
Osaka International Cancer Institute
Osaka, Japan
NHO Kinki-Chuo Chest Medical Center
Sakaishi, Japan
Hokkaido University Hospital
Sapporo, Japan
NHO Yamaguchi - Ube Medical Center
Ube-shi, Japan
Kanagawa Cancer Center
Yokohama, Japan
Tottori University Hospital
Yonago-shi, Japan
Antoni van Leeuwenhoek Ziekenhuis
Amsterdam, Netherlands
VU Medisch Centrum
Amsterdam, Netherlands
Universitair Medisch Centrum Groningen (UMCG) - Parent
Groningen, Netherlands
Uniwersytecki Szpital Kliniczny w Bialymstoku - Dept of Pulmonology & Tuberculosis
Bialystok, Poland
Centrum Pulmonologii i Torakochirurgii w Bystrej
Bystra, Poland
Dr n med. Slawomir Mandziuk Specjalistyczna Praktyka Lekarska
Lublin, Poland
NZOZ Olsztynski Osr. Onkologiczny "Kopernik" Sp.z o.o
Olsztyn, Poland
Przychodnia Med-Polonia Sp. z o.o.
Poznan, Poland
Przychodnia Med-Polonia Sp. z o.o.
Poznan, Poland
Centrum Onkologii-Instytut im. M. Sklodowskiej Curie
Warsaw, Poland
Centrum Onkologii-Instytut im. M. Sklodowskiej Curie
Warsaw, Poland
Dong-A University Hospital
Busan, South Korea
Kosin University Gospel Hospital
Busan, South Korea
Kyungpook National University Medical Center
Daegu, South Korea
National Cancer Center
Goyang-si, South Korea
Chonnam National University Hwasun Hospital
Hwasun-gun, South Korea
Gachon University Gil Medical Center
Incheon, South Korea
Seoul National University Bundang Hospital
Seongnam-si, South Korea
Korea University Anam Hospital
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Severance Hospital, Yonsei University
Seoul, South Korea
The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, South Korea
The Catholic University of Korea, St. Vincent's Hospital
Suwon, South Korea
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital Universitari Quiron Dexeus
Barcelona, Spain
Hospital Universitari Sagrat Cor
Barcelona, Spain
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital General Universitario Santa Lucia
Cartagena, Spain
Hospital de Especialidades de Jerez de la Frontera - Servicio de Oncologia
Jerez de la Frontera, Spain
Hospital Universitario HM Madrid Sanchinarro
Madrid, Spain
Hospital General Universitario Gregorio Marañon
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario HM Madrid Sanchinarro
Madrid, Spain
Hospital Universitario La Paz
Madrid, Spain
Hospital Clinico Universitario Virgen de la Victoria
Málaga, Spain
Hospital Universitario Infanta Sofia
San Sebastián de los Reyes, Spain
Hospital General de Catalunya
Sant Cugat del Vallès, Spain
Hospital Universitario Virgen Macarena
Seville, Spain
Hospital Universitario Nuestra Señora de Valme
Seville, Spain
Hospital Universitario Virgen Macarena
Seville, Spain
Inselspital - Universitaetsspital Bern - Klinik und Poliklinik für Medizinische Onkologie
Bern, Switzerland
Universitaetsspital Zuerich - Klinik fuer Onkologie
Zurich, Switzerland
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
China Medical University Hospital
Taichung, Taiwan
Taichung Veterans General Hospital
Taichung, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Tri-Service General Hospital
Taipei, Taiwan